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Description

The choice between direct and indirect approaches fundamentally reshapes study design, outcome measurements, and interpretability of results

Gramer, Gwendolyn et al

1 Introduction Drug-induced liver injury (DILI) is the most common cause of acute liver injury (Yan et al., 2018) and the Food and Drug Administration has recommended a maximum daily dose of 4 g per day for adults (Orandi et al., 2023)